DNA Methylation: Timekeeper of Biological Age

This recorded webinar on biological aging was published on June 1, 2018 and given by Dr. Steve Horvath.  Cellular senescence, telomere shortening, and changes in gene expression have been well documented to contribute to the aging process. Recently, researchers have found that epigenetic changes, such as the presence of methyl groups in close proximity to CpG dinucleotides located near a gene’s promoter, correlate with age. Technological advances, including microarray analysis and next-generation sequencing, have clarified the relationship between DNA methylation and aging, to the point that such phenomena may even be used to predict one’s chronological age. For a detailed look at the biology of human aging and the dynamics of DNA methylation, The Scientist is bringing together a panel of experts to share their research, to discuss how the epigenome influences aging, and to highlight the approaches scientists are taking to study the possibility of targeting epigenetic modifications for therapeutic intervention.